Analytical Review: Certain Hemolytic Mechanisms in Hemolytic Anemia

ANALYTICAL REVIEW Certain Hemolytic Mechanisms in Heniolytic Anemia

By Enic PONDER, MI)., 1).Sc. T lIE I1E? IAI1KAI3LE A1)VANCE which has taken place (luring the last ten veals in our understanding of the hemolytic anemias is due to tw’o lines of ifl(lUirV having been pursued simultaneously although more or less independently. On the one hand, hematologists have i)ecome more and more aware of the frequency wit.h which hemolytic phenomena occur in a variety of d...

Hemolytic anemia.

Hemolysis presents as acute or chronic anemia, reticulocytosis, or jaundice. The diagnosis is established by reticulocytosis, increased unconjugated bilirubin and lactate dehydrogenase, decreased haptoglobin, and peripheral blood smear findings. Premature destruction of erythrocytes occurs intravascularly or extravascularly. The etiologies of hemolysis often are categorized as acquired or hered...

Complement in hemolytic anemia.

Complement is increasingly being recognized as an important driver of human disease, including many hemolytic anemias. Paroxysmal nocturnal hemoglobinuria (PNH) cells are susceptible to hemolysis because of a loss of the complement regulatory proteins CD59 and CD55. Patients with atypical hemolytic uremic syndrome (aHUS) develop a thrombotic microangiopathy (TMA) that in most cases is attributa...

Hemolytic anemia: Part 2.

[Acquired hemolytic anemia].